|
rs1048943
|
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Ile462Val AG variant and combined AG and GG variant was significantly associated with VTE, adjusted for age, gender, weight and contraceptives (OR=1.362, 95%CI 1.026, 1.809, p=0.033; OR=1.420, 95% CI 1.081, 1.865, p=0.012, respectively); The AG and GG combined variant was still significantly associated with VTE when adjusting further for smoking (OR=1.344, 95%CI 1.019,1.772, p=0.036) A more than two-fold increase for VTE was associated with the Ile462Val combined variant of AG+GG (OR of 2.805, 95% CI 1.250, 6.293, p=0.012) in the smokers.
|
20664892 |
2010 |
|
rs1048943
|
|
Uterine Fibroids
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.
|
18763031 |
2008 |
|
rs1048943
|
|
Uterine Fibroids
|
|
0.040 |
GeneticVariation
|
BEFREE |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (Val158Met) (OR 5.675, 95% CI 2.696-11.942) loci on COMT, rs1048943 (Ile462Val) (OR 4.629, 95% CI 2.216-9.672) and rs4646422 (Gly45Asp) (OR 3.240, 95% CI 1.624-6.461) loci on CYP1A1 and rs1065827 (Ala119Ser) (OR 5.635, 95% CI 2.990-10.619) locus on CYP1B1 were the risk factors to UL development and rs1056836 (Leu432Val) (OR 0.188, 95% CI 0.061-0.575) locus on CYB1B1 may be the protective factor to UL.
|
24777039 |
2014 |
|
rs1048943
|
|
Uterine Fibroids
|
|
0.040 |
GeneticVariation
|
BEFREE |
In addition, haplotype analysis revealed that TG haplotype of the Asp449Asp (T/C) and I</span>le462Val</span> (A/G) polymorphisms could increase the UL risk nearly 4.9-fold.
|
27333216 |
2016 |
|
rs1048943
|
|
Uterine Fibroids
|
|
0.040 |
GeneticVariation
|
BEFREE |
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma.
|
20559649 |
2011 |
|
rs1048943
|
|
T-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associated with increased risk of NHL (OR(AG) = 1.28, 95% CI = 1.07-1.54; OR(AG/GG) = 1.26, 95% CI = 1.06-1.51) and DLBCL (OR(AG) = 1.32, 95% CI = 1.04-1.66; OR(AG/GG) = 1.30, 95% CI = 1.03-1.63), but not T-cell lymphoma.
|
19899130 |
2009 |
|
rs1048943
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published.
|
22359202 |
2012 |
|
rs1048943
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined the association between single nucleotide polymorphisms (SNPs) of CYP1A1 (rs4646421, rs4646422 and rs1048943), GSTM1 and GSTT1 and gastric cancer risk in Japan.
|
27062139 |
2016 |
|
rs1048943
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Potential Cytochrome P450s (CYPs) 1A1 MspI, 1A1 Ile462Val</span>, 1A2*1 F, and/or 1A2*1C polymorphisms have been implicated in gastric cancer risk among different ethnicities.
|
24443269 |
2014 |
|
rs1048943
|
|
Stage IV Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1048943
|
|
Stage IV Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs1048943
|
|
Stage IV Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs1048943
|
|
Stage III Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs1048943
|
|
Stage III Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs1048943
|
|
Stage III Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1048943
|
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs1048943
|
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1048943
|
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs1048943
|
|
Stage IIA Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs1048943
|
|
Stage IIA Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs1048943
|
|
Stage IIA Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1048943
|
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs1048943
|
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1048943
|
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs1048943
|
|
Squamous cell carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
|
16195240 |
2006 |